Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
chloropromazine hydrochloride
CAS: 69-09-0
Molecular Formula: C17H20Cl2N2S
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Names and Identifiers
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Physico-chemical Properties
| Molecular Formula | C17H20Cl2N2S |
| Molar Mass | 355.33 |
| Density | 1.2221 (estimate) |
| Melting Point | 192-196°C |
| Flash Point | 9℃ |
| Water Solubility | >=10 g/100 mL at 24 ºC |
| Solubility | DMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL |
| Appearance | Powder/Solution |
| Color | White to off-white or clear colorless |
| Merck | 14,2185 |
| BRN | 3779989 |
| PH | pH (50g/L, 25℃) : 4.0～5.0 |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive. |
| Sensitive | Sensitive to light and humidity |
| MDL | MFCD00012654 |
| Physical and Chemical Properties | melting point 192-196°C dangerous goods Mark T + |
| Use | This product is a representative drug in the drug of the drug. On the central nervous system, small doses have a stabilizing effect, large doses of continuous use of antipsychotic effect, this product inhibits the hypothalamus temperature regulation center, so that the body temperature with the ambient temperature rise and fall, with other drugs, to reduce the body temperature to normal body temperature, decreased metabolism, called artificial hibernation. It is mainly used for antipsychotics, strengthening the role of hypnotics, anesthetics, analgesics and anticonvulsants. And can be used for the Vomit and intractable hiccup of vomiting and cause artificial hibernation. |
| In vitro study | Chlorpromazine affects microipsc (mIPSCs) by decreasing binding (Kon) and increasing binding disengagement (Koff) of GABAARs. Chlorpromazine regulates the activation of the TRPA1 current in a potential-dependent manner, resulting in an increase in the probability of blocking at positive potentials and opening at negative potentials. |
| In vivo study | Chlorpromazine down-regulates various T-cell-derived lymphokines (IL-2,IFN-γ,IL-4, tumor necrosis factor, and GM-CSF) independently the generation and upregulation of IL-10 secretion in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine mediates SEB-driven Chlorpromazin secretion, accompanied by an enhanced accumulation of IL-10 mRNA. Chlorpromazine protects against lethality in mice, normal or adrenal and guinea pigs against LPS and suppresses serum levels of tumor necrosis factor. When administered 30 minutes before LPS induction, at the same time, or 10 minutes after PS induction, Chlorpromazine prevents lipopolysaccharide lethality, administration after 30 minutes of LPS induction is ineffective. In actinomycin D-induced sensitized LPS mice, Chlorpromazine significantly inhibited the lethality and hepatotoxicity of LPS. Chlorpromazine protects brain tissue from anoxia-induced irreversible loss of synaptic transmission in rats. In) rats, Chlorpromazine also significantly delayed the onset of hypoxia-induced diffuse depression. |
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R26 - Very Toxic by inhalation R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. |
| UN IDs | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | SO1750000 |
| FLUKA BRAND F CODES | 3-10-21 |
| TSCA | Yes |
| HS Code | 29173980 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 225 mg/kg (Goldenthal) |
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Reference
| Reference Show more | 1. Li Peining, Chen Xiu Juan, Jiang Yi et al. Effects of three compounds on chromosome aberration of CHL cells induced by UV [J]. Daily Chemical Industry 2019 49(006):37-380 387. 2. [IF = 4.545] Hui Yang et al."Essential abuse mechanism of araloside A in situ single-pass essential perfusion and in vitro Caco-2 cell model." Biomed Pharmacother. 2018 Oct;106:1563 |
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Standard
Authoritative Data Verified Data
This product is dimethyl-2-chloro-10h-phenothiazine-10-propylamine hydrochloride. The content of C17H19C1N2S • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Trait
Authoritative Data Verified Data
- This product is white or milky white crystalline powder; It has slight odor and hygroscopicity; It gradually changes color in light; The aqueous solution shows acidic reaction.
- This product is soluble in water, ethanol or chloroform, and insoluble in ether or benzene.
melting point
The melting point of this product (General 0612) is 194~198 ℃.
Last Update：2022-01-01 15:34:39
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Differential diagnosis
Authoritative Data Verified Data
- take about 10 mg of this product, add 1 ml of water to dissolve, add 5 drops of nitric acid to show red, gradual light yellow.
- take this product, add hydrochloric acid solution (9-1000) to make the solution per lml, according to UV-visible spectrophotometry (General 0401) determination, there is a maximum absorption at 254nm and 306nm wavelength, at the wavelength of 254nm absorbance is about 0.46.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 391).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:34:40
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Exam
Authoritative Data Verified Data
clarity and color of solution
take 0.50g of this product, Add 10ml of water, shake to dissolve, the solution should be clear and colorless; If it is turbid, compare it with No. 1 turbidity standard solution (General rule 0902 first method), shall not be more concentrated; If the color is developed, it shall not be deeper in comparison with the standard colorimetric solution of Yellow No. 3 or yellow-green No. 3 (General rule 0901 method 1) and shall not show other colors.
Related substances
operation in the dark. Take 20mg of this product, put it in 50ml measuring flask, add mobile phase to dissolve and dilute to the scale, shake, as a test solution; Take appropriate amount of precision, A solution containing 2ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. Column packed with octyl silane bonded silica gel according to high performance liquid chromatography (General 0512); Acetonitrile -0.5% trifluoroacetic acid (adjusted to pH 5.3 with tetramethylethylenediamine)(50:50) the detection wavelength was 254nm. 10 u1 of control solution and 10 u1 of test solution were respectively injected into human liquid chromatograph, and the chromatogram was recorded to 4 times of the retention time of principal component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5%), the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
loss on drying
take this product, dry to constant weight at 105 ℃, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 15:34:40
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 10ml and acetic anhydride 30ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 35.53mg of C17H19C1N2S • HCl.
Last Update：2022-01-01 15:34:41
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Category
Authoritative Data Verified Data
antipsychotics.
Last Update：2022-01-01 15:34:41
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:34:41
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Chlorpromazine Hydrochloride Tablets
Authoritative Data Verified Data
This product contains chlorpromazine hydrochloride (C17H19C1N2S • HCl) should be 93.0% ~ 107.0% of label amount.
trait
This product is sugar-coated tablets, White after removing the coating.
identification
take this product, remove the coating, grind it fine, weigh an appropriate amount of fine powder (about 50mg equivalent to chlorpromazine hydrochloride), add 5ml of water, shake to dissolve chlorpromazine hydrochloride, filter; the filtrate showed the same reaction according to the tests of (1) and (4) for the identification of chlorpromazine hydrochloride.
examination
- the related substances were protected from light. Take an appropriate amount of the fine powder of this product (about 20mg of chlorpromazine hydrochloride), put it in a 50ml measuring flask, add mobile phase to dissolve and dilute to the scale, shake and filter, the filtrate was taken as the test solution; An appropriate amount was taken in a precise amount and quantitatively diluted with the mobile phase to prepare a solution containing 2ug per 1 ml as a control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5%).
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method (General rule 0931 The first method), with water 1000ml as the dissolution medium, the rotation speed is 100 rpm, according to the law, after 30 minutes, take 10ml of the solution for filtration, take the appropriate amount of the continuous filtrate with precise volume, quantitatively dilute with hydrochloric acid solution (9-1000) to make a solution containing 5ug of chlorpromazine hydrochloride per lml, and shake well, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 915), and the elution amount of each tablet was calculated as the absorption coefficient of C17H19C1N2S · HCl was. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 10 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (about 10mg equivalent to promethazine hydrochloride), and put it in a 100ml measuring flask, add solvent [hydrochloric acid solution (9-1000)]70ml, shake to dissolve hydrochloric acid gas promethazine, dilute with solvent to the scale, shake, filter, take a precise amount of continuous filtrate 5ml, dilute the flask with 100ml, add the solvent to the standard, shake well, measure the absorbance at the wavelength of 254nm by UV-Vis spectrophotometry (General rule 0401 ), calculated as the absorption coefficient of C17H19C1N2S • HCl of 915.
category
with chlorpromazine hydrochloride.
specification
(1)12.5mg (2)25mg (3)50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:34:42
Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil - Chlorpromazine Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of chlorpromazine hydrochloride. The content of chlorpromazine hydrochloride (C17H19C1N2S • HCl) shall be between 95.0% and 105.0% of the labeled amount.
trait
This product is colorless or almost colorless clear liquid.
identification
- take an appropriate amount of this product (about 10mg equivalent to chlorpromazine hydrochloride), and show the same reaction according to the identification (1) Test of chlorpromazine hydrochloride.
- the solution under the content measurement item was taken, and the same results were obtained according to the identification item test under the Chlorpromazine Hydrochloride item.
examination
- the pH value should be 3.0 to 5.0 (General 0631).
- the related substances were protected from light. Take an appropriate amount of this product and dilute it with mobile phase to make a solution containing 0.4mg of promethazine hydrochloride in each lml as a test solution, A solution containing 2ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. If there is impurity peak in the chromatogram of the test solution determined by the method for related substances of chlorpromazine hydrochloride, it is larger than the main peak area of the control solution (0.5%). And less than the control solution Main Peak area 10 times (5%) of the impurity peak not more than one. The Peak area of other individual impurities shall not be greater than the main peak area of the control solution (0.5%).
- others should comply with the relevant provisions under injection (General 0102).
Content determination
operation in the dark. Accurately measure an appropriate amount of this product (about 50mg of chlorpromazine hydrochloride), put it in a 200ml measuring flask, dilute it to the scale with hydrochloric acid solution (9-1000), and shake it well, dilute to scale with hydrochloric acid solution (9-1000), shake well, measure absorbance at the wavelength of 254mn by UV-Vis spectrophotometry (General rule 0401), calculated as the absorption coefficient of C17H19C1N2S • HCl of 915.
category
with chlorpromazine hydrochloride.
specification
(l ) lml:10mg ( 2 ) lml:25mg ( 3 ) 2ml:50mg
storage
light shielding, closed storage.
Last Update：2022-01-01 15:34:43
Supplier List
Spot supply
Product Name: Chlorpromazine Visit Supplier Webpage Request for quotationCAS: 69-09-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: chloropromazine hydrochloride Request for quotation
CAS: 69-09-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 69-09-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple Specifications
Product Name: Chlorpromazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 69-09-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Chlorpromazine Visit Supplier Webpage Request for quotationCAS: 69-09-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: chloropromazine hydrochloride Request for quotation
CAS: 69-09-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 69-09-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple Specifications
Product Name: Chlorpromazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 69-09-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History